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A systematic review of the neural bases of psychotherapy for anxiety and related disorders

Using neuroimaging studies that examine the neural bases of anxiety and related disorders, this review shows how psychotherapy and cognitive behavioral therapy (CBT) positively affect the regions of the brain and neural circuits of interest.

MDMA-assisted psychotherapy for treatment of anxiety and other psychological distress related to life threatening illnesses

Individuals suffering from a life-threatening illness (LTI) often experience accompanying anxiety, depression, and existential distress. This study demonstrated that MDMA-assisted psychotherapy can be pursued as a novel therapy for those with LTI, showing improvements in anxiety, depression, sleep, global functioning, well-being, self-compassion, mindfulness, and attitudes regarding death.

Synaptic Loss and the Pathophysiology of PTSD: Implications for Ketamine as a Prototype Novel Therapeutic

The loss of synaptic connectivity associated with post-traumatic stress disorder (PTSD) compromises neuroplasticity, which contributes to symptom chronicity and hinders successful treatment. Ketamine, due to its ability to increase neuroplasticity, shows promise in allowing cognitive and behavioral therapies to be more effective in treating PTSD.

Woman seated with knees pulled up to chest, looking out the window, her hair blocking her face from view.

What is the mechanism of Ketamine's rapid-onset antidepressant effect?

While it is clear that ketamine can produce rapid-onset antidepressant effects in a clinical setting, researchers have also been able to use these discoveries to further understand the pathophysiology of depression. This review provides a comprehensive analysis of years of data in order to further understand the neurophysiology of major depressive disorder (MDD), as well as ketamine’s mechanisms of action that produce antidepressant effects.

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