Slowing aging by design: the rise of NAD+ and sirtuin-activating compounds
Nicotinamide Adenine Dinucleotide (NAD+)
NAD+ is a coenzyme found in every cell that is heavily involved in metabolism and energy production. The sirtuins (SIRT1-7) are a family of NAD+ dependent deacylases with remarkable abilities to prevent diseases and even reverse aspects of aging. Administering NAD+ precursors and sirtuin-activating compounds (STACs), such as resveratrol, has improved organ function, physical endurance, disease resistance, and longevity.
ABOUT THE STUDY
This study continues this important line of research, focusing on using STACs and NAD+ (and NAD+ precursors) to treat inflammatory and metabolic disorders, as well as promote longevity. The unique ability of sirtuins and NAD+ treatments to affect many physiological systems simultaneously draws much clinical attention and shows significant promise, as most medicines only treat one condition while ignoring other comorbidities.
The human body, in all its complexity, requires multifaceted approaches to promoting longevity and overall health, making STACs and NAD+ extremely appealing in the longevity and optimization arena.
Some major benefits provided by these compounds involve glucose regulation, mitochondrial function, DNA protection, injury recovery, cardiac health, muscle wasting, and inflammation. The information cited in this study will inform the development of NAD-boosting molecules and a new class of STACs to restore NAD+ levels and potentially activate all seven sirtuins with a single compound.
